{"id":12011,"date":"2022-06-02T14:03:59","date_gmt":"2022-06-02T07:03:59","guid":{"rendered":"https:\/\/volanphuong.net\/?p=12011"},"modified":"2022-06-02T14:03:59","modified_gmt":"2022-06-02T07:03:59","slug":"thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung","status":"publish","type":"post","link":"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/","title":{"rendered":"Thu\u1ed1c Niranib (Niraparib) 100mg &#8211; Tin vui cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng"},"content":{"rendered":"<div style=\"text-align:center\" class=\"yasr-auto-insert-visitor\"><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_12011' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-12011\">Vui l\u00f2ng nh\u1ea5p v\u00e0o \u0111\u1ec3 \u0111\u00e1nh gi\u00e1<\/div><div id='yasr-visitor-votes-rater-fd6bf003ebc92'\n                                    class='yasr-rater-stars-vv'\n                                    data-rater-postid='12011' \n                                    data-rating='5'\n                                    data-rater-starsize='24'\n                                    data-rater-readonly='false'\n                                    data-rater-nonce='d09f63838c' \n                                    data-issingular='false'\n                                    data-cpt='posts'>\n                                <\/div><div id='yasr-visitor-votes-container-after-stars-fd6bf003ebc92'\n                                             class='yasr-visitor-votes-after-stars'><span class='dashicons dashicons-chart-bar yasr-dashicons-visitor-stats'\n        data-postid='12011' id='yasr-total-average-dashicon-12011'><\/span><span class=\"yasr-total-average-container\"\n                                            id=\"yasr-total-average-text-fd6bf003ebc92\">[Total: <span id=\"yasr-vv-votes-number-container-fd6bf003ebc92\">1<\/span>  Average: <span id=\"yasr-vv-average-container-fd6bf003ebc92\">5<\/span>]<\/span><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div><p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Niranib (Nirapanib) 100mg vi\u00ean nang s\u1ea3n xu\u1ea5t Everest Pharma bao g\u1ed3m ph\u00e2n t\u1eed Niraparib \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00e1i ph\u00e1t bi\u1ec3u m\u00f4 bu\u1ed3ng tr\u1ee9ng, \u1ed1ng d\u1eabn tr\u1ee9ng ho\u1eb7c ung th\u01b0 ph\u00fac m\u1ea1c nguy\u00ean ph\u00e1t.<\/span><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_11 counter-hierarchy counter-decimal ez-toc-grey\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">N\u1ed9i dung b&agrave;i vi\u1ebft <\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class=\"ez-toc-list ez-toc-list-level-1\"><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#thong_tin_chung_ve_thuoc_niranib\" title=\"Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Niranib\">Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Niranib<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#niranib_100mg_la_thuoc_gi\" title=\"Niranib 100mg l\u00e0 thu\u1ed1c g\u00ec?\">Niranib 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#chong_chi_dinh\" title=\"Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh\">Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#duoc_luc_hoc\" title=\"D\u01b0\u1ee3c l\u1ef1c h\u1ecdc\">D\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#duoc_dong_hoc\" title=\"D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\">D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/a><ul class=\"ez-toc-list-level-3\"><li class=\"ez-toc-heading-level-3\"><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#su_hap_thu\" title=\"S\u1ef1 h\u1ea5p th\u1ee5\">S\u1ef1 h\u1ea5p th\u1ee5<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-3\"><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#phan_bo\" title=\"Ph\u00e2n b\u1ed5\">Ph\u00e2n b\u1ed5<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-3\"><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#loai_bo\" title=\"Lo\u1ea1i b\u1ecf\">Lo\u1ea1i b\u1ecf<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-3\"><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#su_trao_doi_chat\" title=\"S\u1ef1 trao \u0111\u1ed5i ch\u1ea5t\">S\u1ef1 trao \u0111\u1ed5i ch\u1ea5t<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-3\"><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#bai_tiet\" title=\"B\u00e0i ti\u1ebft\">B\u00e0i ti\u1ebft<\/a><\/li><\/ul><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#lieu_luong_cach_dung\" title=\"Li\u1ec1u l\u01b0\u1ee3ng &amp; C\u00e1ch d\u00f9ng\">Li\u1ec1u l\u01b0\u1ee3ng &amp; C\u00e1ch d\u00f9ng<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#su_dung_trong_cac_quan_the_dac_biet\" title=\"S\u1eed d\u1ee5ng trong c\u00e1c qu\u1ea7n th\u1ec3 \u0111\u1eb7c bi\u1ec7t\">S\u1eed d\u1ee5ng trong c\u00e1c qu\u1ea7n th\u1ec3 \u0111\u1eb7c bi\u1ec7t<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#phan_ung_phu\" title=\"Ph\u1ea3n \u1ee9ng ph\u1ee5\">Ph\u1ea3n \u1ee9ng ph\u1ee5<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#su_tuong_tac\" title=\"S\u1ef1 t\u01b0\u01a1ng t\u00e1c\">S\u1ef1 t\u01b0\u01a1ng t\u00e1c<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#mang_thai_cho_con_bu\" title=\"Mang thai &amp; Cho con b\u00fa\">Mang thai &amp; Cho con b\u00fa<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#dieu_kien_bao_quan\" title=\"\u0110i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n\">\u0110i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#thuoc_niranib_gia_bao_nhieu\" title=\"Thu\u1ed1c Niranib gi\u00e1 bao nhi\u00eau?\">Thu\u1ed1c Niranib gi\u00e1 bao nhi\u00eau?<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#thuoc_niranib_mua_thuoc_o_dau\" title=\"Thu\u1ed1c Niranib mua thu\u1ed1c \u1edf \u0111\u00e2u?\">Thu\u1ed1c Niranib mua thu\u1ed1c \u1edf \u0111\u00e2u?<\/a><\/li><li class=\"ez-toc-page-1 ez-toc-heading-level-2\"><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/#tuyen_bo_tu_choi_trach_nhiem\" title=\"Tuy\u00ean b\u1ed1 t\u1eeb ch\u1ed1i tr\u00e1ch nhi\u1ec7m\">Tuy\u00ean b\u1ed1 t\u1eeb ch\u1ed1i tr\u00e1ch nhi\u1ec7m<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"thong_tin_chung_ve_thuoc_niranib\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c Niranib<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Th\u01b0\u01a1ng hi\u1ec7u: Niranib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">T\u00ean chung: Niraparib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">T\u00ean th\u01b0\u01a1ng hi\u1ec7u kh\u00e1c: Niranib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">\u0110\u00f3ng g\u00f3i: 30 vi\u00ean<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Nh\u00e0 ch\u1ebf t\u1ea1o: Everest Pharma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean con nh\u1ed9ng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">H\u00e0m l\u01b0\u1ee3ng: 100mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Qu\u1ed1c gia: Bangladesh<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_12014\" aria-describedby=\"caption-attachment-12014\" style=\"width: 507px\" class=\"wp-caption aligncenter\"><img data-attachment-id=\"12014\" data-permalink=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/\" data-orig-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Thuoc-Niranib-Niraparib-100mg-Tin-vui-cho-benh-nhan-ung-thu-buong-trung.jpg\" data-orig-size=\"507,400\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Thu\u1ed1c Niranib (Niraparib) 100mg &#8211; Tin vui cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng\" data-image-description=\"&lt;p&gt;Thu\u1ed1c Niranib (Niraparib) 100mg &#8211; Tin vui cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Thuoc-Niranib-Niraparib-100mg-Tin-vui-cho-benh-nhan-ung-thu-buong-trung.jpg\" data-large-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Thuoc-Niranib-Niraparib-100mg-Tin-vui-cho-benh-nhan-ung-thu-buong-trung.jpg\" loading=\"lazy\" class=\"wp-image-12014 size-full\" src=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Thuoc-Niranib-Niraparib-100mg-Tin-vui-cho-benh-nhan-ung-thu-buong-trung.jpg\" alt=\"Thu\u1ed1c Niranib (Niraparib) 100mg - Tin vui cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng\" width=\"507\" height=\"400\" \/><figcaption id=\"caption-attachment-12014\" class=\"wp-caption-text\"><em><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thu\u1ed1c Niranib (Niraparib) 100mg &#8211; Tin vui cho b\u1ec7nh nh\u00e2n ung th\u01b0 bu\u1ed3ng tr\u1ee9ng<\/span><\/em><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"niranib_100mg_la_thuoc_gi\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Niranib 100mg l\u00e0 thu\u1ed1c g\u00ec?<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\"><a target=\"_blank\" href=\"https:\/\/thuocdactri247.com\/thuoc-dieu-tri\/ung-thu-buong-trung\/thuoc-niranib-100mg-niraparib-dieu-tri-ung-thu-buong-trung\/\" target=\"_blank\" rel=\"noopener\">Niranib 100mg<\/a> l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c h\u00f3a tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf PARP ho\u1eb7c poly ADP ribose polymerase d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Niranib ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p nh\u1eafm m\u1ee5c ti\u00eau trong \u0111\u00f3 n\u00f3 c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc cao \u0111\u1ed1i v\u1edbi PARP1 v\u00e0 PARP2 c\u00f3 t\u00e1c d\u1ee5ng ph\u00e1t hi\u1ec7n t\u1ed5n th\u01b0\u01a1ng DNA v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh s\u1eeda ch\u1eefa. Niranib \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a PARP1 v\u00e0 PARP2 d\u1eabn \u0111\u1ebfn ch\u1ebft t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"chong_chi_dinh\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Qu\u00e1 m\u1eabn v\u1edbi ho\u1ea1t ch\u1ea5t ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o v\u00e0 cho con b\u00fa.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"duoc_luc_hoc\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>D\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Niraparib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u00e1c enzym poly (ADP-ribose) polymerase (PARP), PARP-1 v\u00e0 PARP-2, c\u00f3 vai tr\u00f2 trong vi\u1ec7c s\u1eeda ch\u1eefa DNA. C\u00e1c nghi\u00ean c\u1ee9u trong \u1ed1ng nghi\u1ec7m \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o do niraparib g\u00e2y ra c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzym PARP v\u00e0 t\u0103ng h\u00ecnh th\u00e0nh ph\u1ee9c h\u1ee3p PARP-DNA d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng DNA, apoptosis v\u00e0 ch\u1ebft t\u1ebf b\u00e0o.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">T\u0103ng \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o do Niraparib g\u00e2y ra \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf c\u00e1c d\u00f2ng t\u1ebf b\u00e0o kh\u1ed1i u c\u00f3 ho\u1eb7c kh\u00f4ng thi\u1ebfu h\u1ee5t BRCA1 \/ 2. Niraparib l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n kh\u1ed1i u trong c\u00e1c m\u00f4 h\u00ecnh xenograft chu\u1ed9t c\u1ee7a c\u00e1c d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 \u1edf ng\u01b0\u1eddi b\u1ecb thi\u1ebfu h\u1ee5t BRCA1 \/ 2 v\u00e0 trong c\u00e1c m\u00f4 h\u00ecnh kh\u1ed1i u xenograft c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb b\u1ec7nh nh\u00e2n v\u1edbi s\u1ef1 thi\u1ebfu h\u1ee5t t\u00e1i t\u1ed5 h\u1ee3p t\u01b0\u01a1ng \u0111\u1ed3ng c\u00f3 BRCA1 \/ 2 \u0111\u1ed9t bi\u1ebfn ho\u1eb7c ki\u1ec3u hoang d\u00e3.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"duoc_dong_hoc\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"su_hap_thu\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><b>S\u1ef1 h\u1ea5p th\u1ee5<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a niraparib l\u00e0 kho\u1ea3ng 73%. Sau khi u\u1ed1ng Niraparib, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng, Cmax, \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 3 gi\u1edd. D\u00f9ng \u0111\u1ed3ng th\u1eddi m\u1ed9t b\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o (800-1,000 calo v\u1edbi kho\u1ea3ng 50% t\u1ed5ng l\u01b0\u1ee3ng calo c\u1ee7a b\u1eefa \u0103n l\u00e0 t\u1eeb ch\u1ea5t b\u00e9o) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Niraparib.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"phan_bo\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><b>Ph\u00e2n b\u1ed5<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Niranib li\u00ean k\u1ebft 83,0% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a con ng\u01b0\u1eddi. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn \u200b\u200btrung b\u00ecnh (\u00b1 SD) (Vd \/ F) l\u00e0 1220 (\u00b1 1114) L. Trong m\u1ed9t ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc d\u00e2n s\u1ed1, Vd \/ F c\u1ee7a Niraparib l\u00e0 1074 L \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"loai_bo\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><b>Lo\u1ea1i b\u1ecf<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Sau khi d\u00f9ng nhi\u1ec1u li\u1ec1u h\u00e0ng ng\u00e0y 300 mg Niraparib, th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh (t1 \/ 2) l\u00e0 36 gi\u1edd. Trong m\u1ed9t ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc qu\u1ea7n th\u1ec3, t\u1ed5ng \u0111\u1ed9 thanh th\u1ea3i r\u00f5 r\u00e0ng (CL \/ F) c\u1ee7a niraparib l\u00e0 16,2 L \/ h \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"su_trao_doi_chat\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><b>S\u1ef1 trao \u0111\u1ed5i ch\u1ea5t<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Niraparib \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu b\u1edfi c\u00e1c carboxylesterase (CE) \u0111\u1ec3 t\u1ea1o th\u00e0nh m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng, sau \u0111\u00f3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh glucuronid h\u00f3a.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"bai_tiet\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><b>B\u00e0i ti\u1ebft<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Sau khi s\u1eed d\u1ee5ng m\u1ed9t li\u1ec1u duy nh\u1ea5t 300 mg Niraparib \u0111\u00e1nh d\u1ea5u v\u00f4 tuy\u1ebfn b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, ph\u1ea7n tr\u0103m ph\u1ee5c h\u1ed3i trung b\u00ecnh c\u1ee7a li\u1ec1u \u0111\u00e3 d\u00f9ng trong 21 ng\u00e0y l\u00e0 47,5% (kho\u1ea3ng 33,4% \u0111\u1ebfn 60,2%) trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 38,8% (kho\u1ea3ng 28,3% \u0111\u1ebfn 47,0%) trong ph\u00e2n. Trong c\u00e1c m\u1eabu g\u1ed9p \u0111\u01b0\u1ee3c thu th\u1eadp trong 6 ng\u00e0y, Niraparib kh\u00f4ng thay \u0111\u1ed5i l\u1ea7n l\u01b0\u1ee3t chi\u1ebfm 11% v\u00e0 19% li\u1ec1u s\u1eed d\u1ee5ng \u0111\u01b0\u1ee3c thu h\u1ed3i trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n.<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"lieu_luong_cach_dung\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Li\u1ec1u l\u01b0\u1ee3ng &amp; C\u00e1ch d\u00f9ng<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a Niranib d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u l\u00e0 300 mg (ba vi\u00ean nang 100 mg) u\u1ed1ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">H\u01b0\u1edbng d\u1eabn b\u1ec7nh nh\u00e2n d\u00f9ng li\u1ec1u Niraparib c\u1ee7a h\u1ecd v\u00e0o c\u00f9ng th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y. M\u1ed7i vi\u00ean nang n\u00ean nu\u1ed1t to\u00e0n b\u1ed9. Niraparib c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_12013\" aria-describedby=\"caption-attachment-12013\" style=\"width: 635px\" class=\"wp-caption aligncenter\"><img data-attachment-id=\"12013\" data-permalink=\"https:\/\/volanphuong.net\/thuoc-niranib-niraparib-100mg-tin-vui-cho-benh-nhan-ung-thu-buong-trung\/lieu-luong-cach-dung\/\" data-orig-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung.jpg\" data-orig-size=\"635,476\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;https:\\\/\\\/thuocdactri247.com\\\/&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;thuoc niranib 100mg niraparib dieu tri ung thu buong trung, mua thuoc niranib o dau, cong dung thuoc niraparib la gi - thuoc dac tri 247&quot;,&quot;created_timestamp&quot;:&quot;1566057569&quot;,&quot;copyright&quot;:&quot;https:\\\/\\\/thuocdactri247.com\\\/;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Li\u1ec1u l\u01b0\u1ee3ng &#038; C\u00e1ch d\u00f9ng\" data-image-description=\"&lt;p&gt;Li\u1ec1u l\u01b0\u1ee3ng &#038; C\u00e1ch d\u00f9ng&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung-534x400.jpg\" data-large-file=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung.jpg\" loading=\"lazy\" class=\"size-full wp-image-12013\" src=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung.jpg\" alt=\"Li\u1ec1u l\u01b0\u1ee3ng &amp; C\u00e1ch d\u00f9ng\" width=\"635\" height=\"476\" srcset=\"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung.jpg 635w, https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung-534x400.jpg 534w, https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung-80x60.jpg 80w, https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung-265x198.jpg 265w, https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Lieu-luong-Cach-dung-560x420.jpg 560w\" sizes=\"(max-width: 635px) 100vw, 635px\" \/><figcaption id=\"caption-attachment-12013\" class=\"wp-caption-text\"><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Li\u1ec1u l\u01b0\u1ee3ng &amp; C\u00e1ch d\u00f9ng<\/span><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"su_dung_trong_cac_quan_the_dac_biet\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>S\u1eed d\u1ee5ng trong c\u00e1c qu\u1ea7n th\u1ec3 \u0111\u1eb7c bi\u1ec7t<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cho b\u1ec7nh nh\u00e2n cao tu\u1ed5i (&gt; 65 tu\u1ed5i). D\u1eef li\u1ec7u l\u00e2m s\u00e0ng h\u1ea1n ch\u1ebf \u1edf b\u1ec7nh nh\u00e2n 75 tu\u1ed5i tr\u1edf l\u00ean.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">\u0110\u1ed1i t\u01b0\u1ee3ng tr\u1ebb em: Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a niraparib \u1edf tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean d\u01b0\u1edbi 18 tu\u1ed5i.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Suy th\u1eadn: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cho b\u1ec7nh nh\u00e2n suy th\u1eadn nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng ho\u1eb7c b\u1ec7nh th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i \u0111ang ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o; s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Suy gan: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh. Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng; s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"phan_ung_phu\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Ph\u1ea3n \u1ee9ng ph\u1ee5<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">C\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i (ADR) x\u1ea3y ra&gt; 10% b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u Niraparib l\u00e0 bu\u1ed3n n\u00f4n, gi\u1ea3m ti\u1ec3u c\u1ea7u, m\u1ec7t m\u1ecfi \/ suy nh\u01b0\u1ee3c, thi\u1ebfu m\u00e1u, t\u00e1o b\u00f3n, n\u00f4n m\u1eeda, \u0111au b\u1ee5ng, gi\u1ea3m b\u1ea1ch c\u1ea7u, m\u1ea5t ng\u1ee7, \u0111au \u0111\u1ea7u, gi\u1ea3m c\u1ea3m gi\u00e1c th\u00e8m \u0103n, vi\u00eam m\u0169i h\u1ecdng Ti\u00eau ch\u1ea3y, kh\u00f3 th\u1edf, t\u0103ng huy\u1ebft \u00e1p, kh\u00f3 ti\u00eau, \u0111au l\u01b0ng, ch\u00f3ng m\u1eb7t, ho, nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, \u0111au kh\u1edbp, h\u1ed3i h\u1ed9p v\u00e0 kh\u00f3 ti\u00eau.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">C\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i nghi\u00eam tr\u1ecdng th\u01b0\u1eddng g\u1eb7p nh\u1ea5t&gt; 1% (t\u1ea7n su\u1ea5t \u0111i\u1ec1u tr\u1ecb-c\u1ea5p c\u1ee9u) l\u00e0 gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"su_tuong_tac\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>S\u1ef1 t\u01b0\u01a1ng t\u00e1c<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">\u1ee8c ch\u1ebf c\u00e1c CYP (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 v\u00e0 CYP3A4). C\u1ea3 Niraparib v\u00e0 M1 \u0111\u1ec1u kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf b\u1ea5t k\u1ef3 enzym CYP n\u00e0o \u0111ang ho\u1ea1t \u0111\u1ed9ng chuy\u1ec3n h\u00f3a ch\u1ea5t c\u1ea3n tr\u1edf, c\u1ee5 th\u1ec3 l\u00e0 CYP1A1 \/ 2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 v\u00e0 CYP3A4 \/ 5. M\u1eb7c d\u00f9 s\u1ef1 \u1ee9c ch\u1ebf CYP3A4 \u1edf gan kh\u00f4ng \u0111\u01b0\u1ee3c mong \u0111\u1ee3i, kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf CYP3A4 \u1edf c\u1ea5p \u0111\u1ed9 ru\u1ed9t kh\u00f4ng \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp \u1edf n\u1ed3ng \u0111\u1ed9 Niraparib li\u00ean quan. Do \u0111\u00f3, khuy\u1ebfn c\u00e1o th\u1eadn tr\u1ecdng khi Niraparib k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh chuy\u1ec3n h\u00f3a ph\u1ee5 thu\u1ed9c v\u00e0o CYP3A4 v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ch\u1ea5t c\u00f3 ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb h\u1eb9p (v\u00ed d\u1ee5: ciclosporin, tacrolimus, alfentanil, ergotamine, pimozide, quetiapine v\u00e0 halofantrine).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">C\u1ea3m \u1ee9ng CYP (CYP1A2 v\u00e0 CYP3A4): C\u1ea3 Niraparib v\u00e0 M1 \u0111\u1ec1u kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 trong \u1ed1ng nghi\u1ec7m. Trong \u1ed1ng nghi\u1ec7m, Niraparib c\u1ea3m \u1ee9ng y\u1ebfu CYP1A2 \u1edf n\u1ed3ng \u0111\u1ed9 cao v\u00e0 m\u1ee9c \u0111\u1ed9 li\u00ean quan l\u00e2m s\u00e0ng c\u1ee7a t\u00e1c d\u1ee5ng n\u00e0y s\u1ebd kh\u00f4ng b\u1ecb lo\u1ea1i tr\u1eeb ho\u00e0n to\u00e0n. M1 kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t c\u1ea3m \u1ee9ng CYP1A2. Do \u0111\u00f3, khuy\u1ebfn c\u00e1o th\u1eadn tr\u1ecdng khi k\u1ebft h\u1ee3p niraparib v\u1edbi c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh chuy\u1ec3n h\u00f3a ph\u1ee5 thu\u1ed9c v\u00e0o CYP1A2 v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ch\u1ea5t c\u00f3 ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb h\u1eb9p (v\u00ed d\u1ee5 nh\u01b0 clozapine, theophylline v\u00e0 ropinirole).<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"mang_thai_cho_con_bu\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Mang thai &amp; Cho con b\u00fa<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Th\u1eddi k\u1ef3 mang thai: Kh\u00f4ng c\u00f3 ho\u1eb7c c\u00f3 s\u1ed1 l\u01b0\u1ee3ng h\u1ea1n ch\u1ebf v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Niraparib \u1edf ph\u1ee5 n\u1eef c\u00f3 thai. C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 \u0111\u1ed9c t\u00ednh sinh s\u1ea3n v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u1ed9ng v\u1eadt \u0111\u00e3 kh\u00f4ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh. Tuy nhi\u00ean, d\u1ef1a tr\u00ean c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u00f3, niraparib g\u00e2y h\u1ea1i cho ph\u00f4i thai ho\u1eb7c thai nhi, bao g\u1ed3m t\u00e1c d\u1ee5ng g\u00e2y ch\u1ebft ph\u00f4i v\u00e0 g\u00e2y qu\u00e1i thai, khi d\u00f9ng cho ph\u1ee5 n\u1eef mang thai. Niraparib kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Th\u1eddi k\u1ef3 cho con b\u00fa: Ch\u01b0a r\u00f5 Niranib ho\u1eb7c c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 hay kh\u00f4ng. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho con b\u00fa trong th\u1eddi gian d\u00f9ng Niraparib v\u00e0 trong 1 th\u00e1ng sau khi d\u00f9ng li\u1ec1u cu\u1ed1i c\u00f9ng.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Kh\u1ea3 n\u0103ng sinh s\u1ea3n: Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 kh\u1ea3 n\u0103ng sinh s\u1ea3n. S\u1ef1 gi\u1ea3m sinh tinh c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf chu\u1ed9t v\u00e0 ch\u00f3.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"dieu_kien_bao_quan\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>\u0110i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">B\u1ea3o qu\u1ea3n trong \u0111i\u1ec1u ki\u1ec7n m\u00e1t v\u00e0 kh\u00f4. Kh\u00f4ng l\u01b0u tr\u1eef tr\u00ean 30 \u00b0 C.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">Kh\u00f4ng d\u00f9ng Niranib n\u1ebfu n\u00f3 nghi ng\u1edd ti\u1ebfp x\u00fac v\u1edbi nhi\u1ec7t \u0111\u1ed9 l\u1edbn h\u01a1n 40 \u00b0 C ho\u1eb7c 104 \u00b0 F.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; font-family: 'times new roman', times, serif; font-size: 12pt;\">\u0110\u1ec3 Niraparib xa t\u1ea7m tay v\u00e0 t\u1ea7m nh\u00ecn c\u1ee7a tr\u1ebb em.<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"thuoc_niranib_gia_bao_nhieu\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 18pt;\"><b>Thu\u1ed1c Niranib gi\u00e1 bao nhi\u00eau?<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Tham kh\u1ea3o gi\u00e1 thu\u1ed1c Niranib 100mg Niraparib \u0111i\u1ec1u tr\u1ecb ung th\u01b0 bu\u1ed3ng tr\u1ee9ng t\u1ea1i \u0111\u00e2y: <a target=\"_blank\" href=\"https:\/\/thuocdactri247.com\/thuoc-dieu-tri\/ung-thu-buong-trung\/thuoc-niranib-100mg-niraparib-dieu-tri-ung-thu-buong-trung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/thuocdactri247.com\/thuoc-dieu-tri\/ung-thu-buong-trung\/thuoc-niranib-100mg-niraparib-dieu-tri-ung-thu-buong-trung\/<\/a><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"thuoc_niranib_mua_thuoc_o_dau\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><span id=\"thuoc_lynib_mua_thuoc_o_dau\" class=\"ez-toc-section\"><\/span><span style=\"font-size: 18pt;\"><b>Thu\u1ed1c Niranib mua thu\u1ed1c \u1edf \u0111\u00e2u?<\/b><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-size: 12pt; font-family: 'times new roman', times, serif;\">Li\u00ean h\u1ec7: 0901771516 <\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"tuyen_bo_tu_choi_trach_nhiem\"><\/span><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><span id=\"tuyen_bo_tu_choi_trach_nhiem\" class=\"ez-toc-section\"><\/span><span style=\"font-size: 18pt;\"><b>Tuy\u00ean b\u1ed1 t\u1eeb ch\u1ed1i tr\u00e1ch nhi\u1ec7m<\/b><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">N\u1ed9i dung c\u1ee7a <span style=\"color: #0000ff;\"><strong><em>Volanphuong.net<\/em><\/strong><\/span> ch\u1ec9 nh\u1eb1m m\u1ee5c \u0111\u00edch cung c\u1ea5p th\u00f4ng tin v\u1ec1 Niranib 100mg Niraparib\u00a0v\u00e0 kh\u00f4ng nh\u1eb1m m\u1ee5c \u0111\u00edch thay th\u1ebf cho t\u01b0 v\u1ea5n, ch\u1ea9n \u0111o\u00e1n ho\u1eb7c \u0111i\u1ec1u tr\u1ecb y t\u1ebf chuy\u00ean nghi\u1ec7p. Vui l\u00f2ng t\u00ecm l\u1eddi khuy\u00ean c\u1ee7a b\u00e1c s\u0129 ho\u1eb7c nh\u00e0 cung c\u1ea5p y t\u1ebf \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n kh\u00e1c v\u1edbi b\u1ea5t k\u1ef3 c\u00e2u h\u1ecfi n\u00e0o c\u00f3 li\u00ean quan \u0111\u1ebfn t\u00ecnh tr\u1ea1ng y t\u1ebf c\u1ee7a b\u1ea1n. \u0110\u1eebng b\u1ecf qua l\u1eddi khuy\u00ean y t\u1ebf chuy\u00ean nghi\u1ec7p ho\u1eb7c tr\u00ec ho\u00e3n t\u00ecm ki\u1ebfm n\u00f3 v\u00ec nh\u1eefng g\u00ec b\u1ea1n \u0111\u00e3 \u0111\u1ecdc tr\u00ean trang web n\u00e0y.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\"><strong><b>Ngu\u1ed3n uy t\u00edn:<\/b><\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thu\u1ed1c Niranib c\u1eadp nh\u1eadt ng\u00e0y 02\/03\/2021: <a target=\"_blank\" href=\"https:\/\/emergencydrug.com\/shop\/niranib-niraparib-100-mg\/\" target=\"_blank\" rel=\"noopener\">https:\/\/emergencydrug.com\/shop\/niranib-niraparib-100-mg\/<\/a><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 12pt;\">Thu\u1ed1c Niranib c\u1eadp nh\u1eadt ng\u00e0y 02\/03\/2021: <a target=\"_blank\" href=\"https:\/\/thuocdactri247.com\/thuoc-dieu-tri\/ung-thu-buong-trung\/thuoc-niranib-100mg-niraparib-dieu-tri-ung-thu-buong-trung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/thuocdactri247.com\/thuoc-dieu-tri\/ung-thu-buong-trung\/thuoc-niranib-100mg-niraparib-dieu-tri-ung-thu-buong-trung\/<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vui l\u00f2ng nh\u1ea5p v\u00e0o \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 [Total: 1 Average: 5]Niranib (Nirapanib) 100mg vi\u00ean nang s\u1ea3n xu\u1ea5t Everest Pharma bao g\u1ed3m ph\u00e2n t\u1eed Niraparib \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00e1i ph\u00e1t bi\u1ec3u m\u00f4 bu\u1ed3ng tr\u1ee9ng, \u1ed1ng d\u1eabn tr\u1ee9ng ho\u1eb7c ung th\u01b0 ph\u00fac m\u1ea1c nguy\u00ean ph\u00e1t. N\u1ed9i dung b&agrave;i vi\u1ebft Th\u00f4ng tin chung v\u1ec1 thu\u1ed1c [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":12014,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[2401],"tags":[8243,8241,2030,8242,8244,8239,2027,8240,8245,2035],"modified_by":"V\u00f5 Lan Ph\u01b0\u01a1ng","yasr_visitor_votes":{"number_of_votes":1,"sum_votes":5,"stars_attributes":{"read_only":false,"span_bottom":false}},"jetpack_featured_media_url":"https:\/\/volanphuong.net\/wp-content\/uploads\/2022\/06\/Thuoc-Niranib-Niraparib-100mg-Tin-vui-cho-benh-nhan-ung-thu-buong-trung.jpg","jetpack_publicize_connections":[],"jetpack_shortlink":"https:\/\/wp.me\/pcysWX-37J","jetpack-related-posts":[{"id":12007,"url":"https:\/\/volanphuong.net\/lynib-100mg-olaparib-thuoc-dieu-tri-ung-thu-hieu-qua\/","url_meta":{"origin":12011,"position":0},"title":"Lynib 100mg Olaparib - Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 hi\u1ec7u qu\u1ea3","date":"01\/06\/2022","format":false,"excerpt":"Lynib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf poly (ADP-ribose) polymerase (PARP) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 bu\u1ed3ng tr\u1ee9ng, ung th\u01b0 v\u00fa, ung th\u01b0 tuy\u1ebfn t\u1ee5y v\u00e0 ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t. Lynib 100mg l\u00e0 thu\u1ed1c g\u00ec? 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